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Updated: May 26, 2026

Generation of Induced Pluripotent Stem Cell-Derived iTenocytes via Combined Scleraxis Overexpression and 2D Uniaxial Tension
Published on: March 1, 2024
Stem cells for augmenting tendon repair
Lawrence V Gulotta1, Salma Chaudhury, Daniel Wiznia
1Sports Medicine and Shoulder Service, Hospital for Special Surgery, 535 E 70th Street, New York, NY 10021, USA.
Abstract:
Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions remain to be answered before stem cells can be used clinically. Specifically, the type of stem cell, the amount of cells, and the proper combination of growth factors or mechanical stimuli to induce differentiation all remain to be seen. This paper outlines the current literature on the use of stem cells for tendon augmentation.
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