Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dual SYK-HDAC Inhibitor Elicits Striking Efficacy against Acute Myeloid Leukemia: Rational Design, Synthesis, and Biological Evaluation.

Journal of medicinal chemistry·2026
Same author

Flavonoids as Dual Topoisomerase I and II Inhibitors: Mechanistic Insights and Emerging Anticancer Strategies.

Chemistry & biodiversity·2026
Same author

Phytochemicals as Promising Therapeutics in Cancer Prevention and Treatment: Mechanisms and Applications.

Current cancer drug targets·2026
Same author

Corrigendum to: Recent Developments in Oral Drug Delivery of Prokinetic Agents: Nanoparticles and Beyond.

Current drug delivery·2026
Same author

Hybrid nanogel system of quercetin-loaded squalene NLCs with zinc-HA network for dry eye syndrome.

International journal of biological macromolecules·2026
Same author

Recent Advances in Bioactive Flavonoids-based Nanotherapeutics as Promising Neuroprotectants in Epilepsy.

Current aging science·2026

Related Experiment Video

Updated: May 26, 2026

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Development of transmucosal patch using nanofibers.

Harleen Grewal1, Sanjay R Dhakate, Amit K Goyal

  • 1Nanomedicine Research Centre, Department of Pharmaceutics, Indo-Soviet Friendship, College of Pharmacy, Moga, Punjab, India.

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
|December 24, 2011
PubMed
Summary
This summary is machine-generated.

Novel electrospun polycaprolactone (PCL) nanofibers offer a new approach for transmucosal drug delivery. These PCL nanofibers demonstrate sustained release of diclofenac sodium, potentially improving therapeutic efficacy for NSAID delivery.

More Related Videos

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes
07:41

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Published on: July 12, 2024

Related Experiment Videos

Last Updated: May 26, 2026

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices
08:26

Dissolving Microneedle Array Patches Manufactured By Solvent Casting Technique and Essential Characterization of Microneedle-Based Biomedical Devices

Published on: January 30, 2026

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes
07:41

Fabrication and Characterization of Microneedle Patches for Loading and Delivery of Exosomes

Published on: July 12, 2024

Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biomedical Engineering

Background:

  • Diclofenac sodium is a widely used non-steroidal anti-inflammatory drug (NSAID).
  • Traditional oral administration of NSAIDs can lead to gastrointestinal side effects.
  • Transmucosal drug delivery offers an alternative route to bypass first-pass metabolism and reduce systemic toxicity.

Purpose of the Study:

  • To develop and characterize novel transmucosal drug delivery patches of diclofenac sodium.
  • To utilize electrospun polycaprolactone (PCL) nanofibers for enhanced drug delivery.
  • To evaluate the drug loading and in-vitro release profile of the developed nanofiber patches.

Main Methods:

  • Polycaprolactone (PCL) nanofibers were fabricated using electrospinning with varying polymer concentrations.
  • Nanofiber formulations were characterized using Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR).
  • Drug loading efficiency and in-vitro drug release studies were conducted using a Franz diffusion cell.

Main Results:

  • Electrospinning of 13% PCL resulted in fracture-free, non-beaded, ultrafine nanofibers with an average diameter of 120 nm.
  • The PCL nanofiber formulations exhibited sustained drug release behavior over the study period.
  • FTIR analysis confirmed the successful incorporation of diclofenac sodium within the PCL nanofibers.

Conclusions:

  • Electrospun PCL nanofibers are a promising platform for transmucosal drug delivery of diclofenac sodium.
  • The developed nanofiber patches demonstrate sustained release characteristics, potentially leading to improved therapeutic efficacy.
  • This approach offers a viable alternative for NSAID administration, minimizing potential adverse effects associated with oral delivery.