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Related Concept Videos

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional levelĀ in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Experimental RNAi02:15

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional levelĀ in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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Related Experiment Video

Updated: May 26, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Matrix systems for siRNA delivery.

B Naeye1, K Raemdonck, K Remaut

  • 1Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium.

Current Topics in Medicinal Chemistry
|December 27, 2011
PubMed
Summary
This summary is machine-generated.

Matrix systems offer promising delivery of small interfering RNA (siRNA) for RNA interference (RNAi) therapies. These systems help siRNA navigate cellular barriers to reach the cytoplasm for treating various disorders.

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Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy
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Published on: June 21, 2013

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Last Updated: May 26, 2026

Porous Silicon Microparticles for Delivery of siRNA Therapeutics
08:31

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Published on: January 15, 2015

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery
09:09

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy
15:55

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy

Published on: June 21, 2013

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Drug Delivery Systems

Background:

  • RNA interference (RNAi) is a therapeutic strategy for various disorders.
  • RNAi mediators like small interfering RNA (siRNA) must overcome cellular barriers to reach the cytoplasm.
  • Effective delivery systems are crucial for successful RNAi-based therapies.

Purpose of the Study:

  • To review recent advancements in matrix and hybrid systems for siRNA delivery.
  • To highlight the potential of matrix systems in overcoming delivery challenges for RNAi therapeutics.
  • To discuss the properties of matrix systems that facilitate siRNA transport to target tissues.

Main Methods:

  • Literature review of recently developed matrix and hybrid systems for siRNA delivery.
  • Analysis of the properties and mechanisms of these delivery systems.
  • Discussion of their potential applications in RNAi-based treatments.

Main Results:

  • Matrix systems demonstrate significant potential for enhancing siRNA delivery.
  • Hybrid systems offer versatile approaches for overcoming biological barriers.
  • Recent developments show promise in improving the efficiency and targeting of siRNA delivery.

Conclusions:

  • Matrix and hybrid systems are valuable tools for advancing RNAi therapeutics.
  • Further research into these delivery systems can accelerate the clinical application of RNAi.
  • Optimized delivery is key to unlocking the full potential of RNA interference for disease treatment.