Related Experiment Video
Updated: May 26, 2026
Semi-automated Biopanning of Bacterial Display Libraries for Peptide Affinity Reagent Discovery and Analysis of Resulting Isolates
Published on: December 6, 2017
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012
Bruce J Melancon1, Alexander P Lamers, Thomas M Bridges
1Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Abstract:
This Letter describes the continued optimization of an MLPCN probe molecule (ML012) through an iterative parallel synthesis approach. After exploring extensive modifications throughout the parent structure, we arrived at a more highly M(1)-selective antagonist, compound 13l (VU0415248). Muscarinic subtype selectivity across all five human and rat receptors for 13l, along with rat selectivity for the lead compound (ML012), is presented.
