Related Experiment Video
Updated: May 26, 2026
Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
[Vitamin D status in osteoporotic postmenopausal women taking oral recommended vitamin D supplementation]
José Ivorra1, Elia Valls, Nagore Fernández-Llanio Comella
1Servicio de Reumatología, Hospital Universitario Dr. Peset, Valencia, Spain. ivorra_jos@gva.es
Background And Objective:
To assess the effectiveness of currently recommended daily intakes of vitamin D (25[OH]D) to bring optimal serum concentrations (30ng/ml) in postmenopausal osteoporotic women.
Patients And Methods:
We reviewed 25(OH)D serum concentrations in 165 consecutive osteoporotic postmenopausal women who were taking oral vitamin D daily supplements above 800IU during at least 3 months. The proportion of patients who achieved 25(OH)D levels of 20, 30 and 40ng/ml were compared according to daily vitamin D intakes (group 1: 800-1,000IU, group 2: 1,001-1,600IU, group 3:>1,600IU).
Results:
Mean patient age was 69 (10) years. Percentage of patients with serum 25(OH)D levels above 20ng/ml was 79.5% (63.5-88.5%), 92.7%(78.7-96%) and 97.6% (90.6-100%) in group 1, 2, and 3 patients, respectively (P=.009). Serum levels above 30ng/ml were achieved in 27.7% (14.7-44.7%), 53.6% (37.6-70%) and 90.2% (81.2-96.6%), respectively (P<.001). Serum levels above 40ng/ml were reached in 7.2% (1-20%), 24.4% (12-40%) and 61% (49-72%), respectively (P<.001).
Conclusion:
Daily reference intakes of vitamin D supplements (800-1,000IU) may be insufficient to achieve optimal serum levels of vitamin D in postmenopausal osteoporotic women.
Related Concept Videos
01:25Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
01:23Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
01:31Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:21Skeleton and Calcium Homeostasis
01:22Connective Tissue Cell Types
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...