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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

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Related Experiment Video

Updated: May 26, 2026

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells
09:43

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells

Published on: March 8, 2024

Cytokines and Behcet's disease.

Z Y Zhou1, S L Chen, N Shen

  • 1Shanghai Clinical Centre of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Rheumatology, China.

Autoimmunity Reviews
|December 27, 2011
PubMed
Summary
This summary is machine-generated.

Behcet's Disease involves a complex cytokine network. Targeting key cytokines offers potential therapeutic strategies for this systemic vasculitis.

Related Experiment Videos

Last Updated: May 26, 2026

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells
09:43

Microfluidic Approach to Resolve Simultaneous and Sequential Cytokine Secretion of Individual Polyfunctional Cells

Published on: March 8, 2024

Area of Science:

  • Immunology
  • Rheumatology
  • Genetics

Background:

  • Behcet's Disease (BD) is a systemic vasculitis with unknown causes.
  • A complex cytokine network is implicated in BD's onset, progression, and organ damage.
  • Cytokines, including Th1, Th2, Th17 types, and chemokines, play a role in BD pathogenesis.

Purpose of the Study:

  • To review the role of cytokines in Behcet's Disease pathogenesis.
  • To explore the therapeutic potential of targeting cytokine networks in BD.
  • To identify specific cytokines associated with BD manifestations and genetic predispositions.

Main Methods:

  • Literature review of studies on cytokines in Behcet's Disease.
  • Analysis of cytokine profiles in relation to disease activity and organ involvement.
  • Examination of genetic associations between cytokine gene polymorphisms and BD susceptibility.

Main Results:

  • Specific cytokines like IL6, IP10, IL17, and IL18 are linked to BD neurological and ocular manifestations.
  • Cytokines such as IL8, RANTES, and MIP-1α correlate with disease activity.
  • IL10 may have a protective effect, showing negative relevance to disease activity.
  • Genetic studies reveal associations between BD and SNPs in cytokine genes (e.g., IL1, TNFα, IL10, IL23R-IL12RB2 region).

Conclusions:

  • The intricate cytokine network is central to Behcet's Disease pathogenesis.
  • Targeting specific cytokines or their blockers (e.g., Anti-TNFα, IL1 receptor antagonist) shows therapeutic promise.
  • Further research into local cytokine profiles and multi-center studies are warranted for comprehensive understanding and treatment of BD.