[Endometrial cancers and predisposition]

Area of Science:

• Oncology
• Genetics
• Hereditary Cancer Syndromes

Context:

• Approximately 5% of endometrial cancers are linked to inherited predispositions.
• Identifying these genetic links is essential for proactive cancer management.
• Key indicators include young age at diagnosis and family history of cancer.

Purpose:

• To systematically explore genetic predispositions in endometrial cancer.
• To detail Lynch syndrome, its clinical features, molecular basis, and risks.
• To review management guidelines and other rare hereditary predispositions.

Summary:

• This review focuses on Lynch syndrome as the primary cause of hereditary endometrial cancer.
• It covers clinical manifestations, molecular mechanisms, cancer risks, and management strategies.
• Less common hereditary predispositions are also briefly discussed.

Impact:

• Facilitates early identification of at-risk individuals and families.
• Enables personalized management strategies for endometrial cancer.
• Improves understanding of hereditary cancer syndromes and their implications.