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Published on: June 9, 2023
Impact of cyclooxygenase-2 in breast cancer
Friederike Hoellen1, Katharina Kelling, Christine Dittmer
1Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Luebeck Campus, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Abstract:
Prostaglandin metabolism plays a pivotal role in inflammatory processes and has also been demonstrated to have a role in carcinogenesis, tumor differentiation and tumor growth in breast cancer. Cyclooxygenase-2 (COX-2) is the key involved enzyme, as it triggers prostaglandin synthesis. We reviewed the current literature regarding the impact of prostaglandin metabolism on breast cancer and illustrated the current evidence of the COX-2 influence on breast cancer, delineating possible future prophylactic and therapeutic strategies.
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