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Related Experiment Video

Updated: Jul 2, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
13:35

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

Published on: May 17, 2024

Pre-Pectoral Breast Reconstruction after Mastectomy: Current Evidence, Knowledge Gaps, and Rationale for the

Rosa Di Micco1, Lorenzo Scardina2, Edoardo Botteri3

  • 1Breast Surgery Unit, IRCCS Ospedale San Raffaele, Milan, Italy.

Breast Care (Basel, Switzerland)
|July 1, 2026
PubMed

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Summary

The I-PREPARE trial investigates pre-pectoral implant-based breast reconstruction (IBR) outcomes, focusing on oncological safety and complications, especially after radiation therapy (RT). This study provides crucial data for improving breast reconstruction techniques and patient care.

Area of Science:

  • Oncology
  • Plastic Surgery
  • Clinical Trials

Background:

  • Pre-pectoral implant-based breast reconstruction (IBR) offers an alternative to subpectoral methods.
  • Long-term oncological safety and complication profiles, particularly with radiation therapy (RT), require further investigation.
  • Existing evidence is limited by retrospective designs and short follow-up periods.

Purpose of the Study:

  • To generate high-quality data on the oncological safety, complications, aesthetic results, and patient-reported outcomes of pre-pectoral IBR.
  • To specifically evaluate the impact of radiation therapy (RT) on pre-pectoral IBR outcomes.
  • To address knowledge gaps and inform clinical decision-making in breast reconstruction.

Main Methods:

  • Prospective, international, observational cohort study (I-PREPARE trial, EUBREAST-11R).
Keywords:
Acellular dermal matricesBreast cancerImplant-based breast reconstructionPolyurethane implantPre-pectoral breast reconstructionSynthetic meshes

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Last Updated: Jul 2, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Published on: May 17, 2024

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Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial

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  • Enrolling 1,236 adult women undergoing nipple- or skin-sparing mastectomy followed by pre-pectoral IBR.
  • Primary endpoint: implant loss at 3 months; secondary endpoints: complications, reoperations, quality of life, adjuvant treatment timing; tertiary endpoints: oncological outcomes.

    • Main Results:

    • The study is designed to collect comprehensive data on implant loss, complications, quality of life, and oncological outcomes.
    • Data collection utilizes secure electronic case report forms (eCRF) and the EUBreast patient App.
    • The trial aims to provide robust evidence on the safety and efficacy of pre-pectoral IBR.

    Conclusions:

    • The I-PREPARE trial will provide essential real-world evidence on pre-pectoral IBR.
    • Findings will contribute to better patient selection, surgical planning, and multidisciplinary care.
    • This research is vital for advancing breast reconstruction practices and improving patient outcomes.