Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Binary Fission01:26

Binary Fission

Binary fission is the primary mode of asexual reproduction in prokaryotes, such as bacteria. It results in the production of two genetically identical daughter cells. This highly efficient process ensures the rapid propagation of bacterial populations under favorable conditions and involves coordinated cellular and molecular events.DNA Replication and SeparationThe process begins with the replication of the bacterial chromosome. The circular DNA molecule unwinds at a specific origin of...
Binary Fission01:20

Binary Fission

Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in the Archaea and Bacteria domains reproduce using binary fission, in which a parent cell splits into two parts that can each grow to the size of the original parent cell. This asexual method of reproduction produces cells that are all genetically identical.
Anaphase A and B01:39

Anaphase A and B

Microtubules form through the end-to-end polymerization of tubulin heterodimers. Kinetochore microtubules originate from the spindle poles, and their plus-ends connect with the kinetochores on sister-chromatids. Ndc80 protein complexes, present on the kinetochore, form low-affinity links with the plus end of these kinetochore microtubules.
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Separation of Sister Chromatids02:17

Separation of Sister Chromatids

At the transition from prophase to metaphase, there is a reduction in cohesion along the chromosomal arms, resulting in the resolution of sister chromatids. However, residual cohesin connections remain to hold the sister chromatids together until the transition from metaphase to anaphase. The residual connection prevents any premature separation of sister chromatids, blocking the risks of aneuploidy within the daughter cells.
At the onset of anaphase, separase, a proteolytic enzyme, is...
Cohesins02:20

Cohesins

Cohesin protein complexes are a molecular glue that holds two sister chromatids together. They play an important role both in mitosis and meiosis. In mitosis, all cohesin complexes present on the chromosomes are removed before the start of the anaphase stage.
Cohesin complexes in Meiotic Division
Meiosis involves two distinct rounds of chromosomal segregation and cell divisions— Meiosis I followed by Meiosis II – producing four daughter cells. Meiosis I includes the separation of homologous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A decade of antimicrobial resistance in <i>Vibrio</i> spp.: genomic and functional insights.

Microbiology spectrum·2026
Same author

Bacteriophage based live biotherapeutics: A novel approach to tackle drug resistant infectious diseases.

Progress in molecular biology and translational science·2026
Same author

DNA topoisomerase I acts as supercoiling sensor for bacterial transcription elongation.

Nature structural & molecular biology·2025
Same author

Persistence mechanisms of Crohn's disease-associated adherent invasive <i>Escherichia coli</i> within macrophages.

Gut microbes·2025
Same author

Dynamic quinone repertoire accompanied the diversification of energy metabolism in Pseudomonadota.

The ISME journal·2024
Same author

MatP local enrichment delays segregation independently of tetramer formation and septal anchoring in Vibrio cholerae.

Nature communications·2024
Same journal

Conditional Immortalization of Human Cardiac Fibroblasts for Pro-Fibrotic and Anti-Fibrotic Drug Screening.

Frontiers in bioscience (Landmark edition)·2026
Same journal

NF-κB Involvement in Glaucoma-Associated Neuroinflammation: Focus on Glial Cells.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Revealing the Molecular Network of Pattern-Triggered Immunity (PTI) Signal Transduction.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Decoding Immune Mechanisms in BCG-unresponsive Non-muscle Invasive Bladder Cancer.

Frontiers in bioscience (Landmark edition)·2026
Same journal

β-Ecdysterone Attenuates Ang II-Induced Senescence in Human Aortic Smooth Muscle Cells via Autophagy Activation and ROS Suppression Through AKT/mTOR Pathway Inhibition.

Frontiers in bioscience (Landmark edition)·2026
Same journal

Exploration of the Role of M2 Macrophages in Hepatocellular Carcinoma: Insights into Disulfidptosis and Cellular Interactions.

Frontiers in bioscience (Landmark edition)·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
06:39

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Bacterial chromosome segregation.

Christophe Possoz1, Ivan Junier, Olivier Espeli

  • 1Centre de Genetique Moleculaire, CGM-CNRS-UPR3404, Avenue de la terrasse, 91198 Gif sur Yvette, France.

Frontiers in Bioscience (Landmark Edition)
|December 29, 2011
PubMed
Summary
This summary is machine-generated.

Bacterial chromosome segregation ensures accurate genome division. Key proteins and cellular mechanisms, studied in model organisms, are crucial for this process.

More Related Videos

Site-specific Bacterial Chromosome Engineering: &#934;C31 Integrase Mediated Cassette Exchange (IMCE)
08:21

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Published on: March 16, 2012

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle
08:02

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle

Published on: April 8, 2015

Related Experiment Videos

Last Updated: May 26, 2026

Live Cell Imaging of Chromosome Segregation During Mitosis
06:39

Live Cell Imaging of Chromosome Segregation During Mitosis

Published on: March 14, 2018

Site-specific Bacterial Chromosome Engineering: &#934;C31 Integrase Mediated Cassette Exchange (IMCE)
08:21

Site-specific Bacterial Chromosome Engineering: ΦC31 Integrase Mediated Cassette Exchange (IMCE)

Published on: March 16, 2012

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle
08:02

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle

Published on: April 8, 2015

Area of Science:

  • Microbiology
  • Molecular Biology
  • Cell Biology

Background:

  • Cell division requires precise genome segregation.
  • Recent advances have clarified bacterial chromosome segregation mechanisms.

Purpose of the Study:

  • To review bacterial chromosome segregation mechanisms.
  • To highlight insights gained from model organisms like E. coli, B. subtilis, C. crescentus, and V. cholerae.

Main Methods:

  • Literature review focusing on model organism studies.
  • Analysis of nucleoid positioning and chromosomal locus dynamics.
  • Examination of kinetic and biophysical aspects.
  • Identification of key proteins involved.

Main Results:

  • Detailed understanding of nucleoid positioning within bacterial cells.
  • Characterization of specific chromosomal locus dynamics during segregation.
  • Insights into the kinetic and biophysical principles governing segregation.
  • Identification and description of essential segregation proteins.

Conclusions:

  • Model organism studies have significantly advanced our understanding of bacterial chromosome segregation.
  • A comprehensive overview of the key factors and processes involved is now available.