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Updated: May 26, 2026
03:53
Extracellular Vesicle Tissue Factor Activity Assay
Published on: December 29, 2023
Tissue factor in health and disease
Julie C Williams1, Nigel Mackman
1Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, North Carolina, USA.
Frontiers in Bioscience (Elite Edition)
|December 29, 2011
Summary
Tissue Factor (TF) initiates blood clotting upon injury. This review explores TF
Area of Science:
- Hemostasis and Thrombosis
- Cellular Biology
- Pathology
Background:
- Tissue Factor (TF) is the primary initiator of the extrinsic coagulation cascade.
- Normally sequestered from blood, TF is exposed upon vascular injury.
- TF initiates both coagulation and intracellular signaling via protease-activated receptors.
Purpose of the Study:
- To review the diverse roles of Tissue Factor in physiological and pathological conditions.
- To discuss therapeutic strategies aimed at mitigating aberrant TF expression.
Main Methods:
- Literature review of scientific articles on Tissue Factor.
- Analysis of TF's role in coagulation and cellular signaling pathways.
- Examination of TF's involvement in various disease states.
Main Results:
- TF activation is a critical event following vascular injury, leading to thrombin generation.
- Pathological TF expression is implicated in numerous diseases.
- TF signaling contributes to cellular responses beyond coagulation.
Conclusions:
- Tissue Factor plays a pivotal role in hemostasis and disease pathogenesis.
- Targeting TF expression presents a potential therapeutic avenue for TF-driven diseases.
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