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Related Concept Videos

Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...

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Related Experiment Video

Updated: May 26, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
13:36

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

Sialyltransferases functions in cancers.

Anne Harduin-Lepers1, Marie-Ange Krzewinski-Recchi, Florent Colomb

  • 1Unite de Glycobiologie Structurale et Fonctionnelle, Universite Lille Nord de France, Lille1, CNRS UMR 8576, F-59655 Villeneuve d'Ascq, France. anne.harduin@univ-lille1.fr

Frontiers in Bioscience (Elite Edition)
|December 29, 2011
PubMed
Summary
This summary is machine-generated.

Elevated sialylated tumor antigens on cancer cells are linked to altered sialyltransferase activity. This review explores human sialyltransferases, their role in cancer antigen expression, and research tools.

Related Experiment Videos

Last Updated: May 26, 2026

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes
13:36

Generation of Monocyte-Derived Dendritic Cells with Differing Sialylated Phenotypes

Published on: October 20, 2023

Area of Science:

  • Biochemistry
  • Glycobiology
  • Cancer Biology

Background:

  • Sialylated tumor-associated carbohydrate antigens are overexpressed on cancer cells and in biological fluids.
  • This overexpression is linked to dysregulated sialyltransferase activity but precise mechanisms are unclear.

Purpose of the Study:

  • To review human sialyltransferases involved in altered sialylated tumor antigen expression.
  • To discuss the molecular basis of their regulation in cancer.
  • To summarize tools for studying these antigens in pathology.

Main Methods:

  • Literature review of human sialyltransferases.
  • Analysis of molecular mechanisms in cancer cells.
  • Survey of research and clinical tools.

Main Results:

  • Identified twenty human sialyltransferases involved in glycoconjugate sialylation.
  • Detailed the link between sialyltransferases and tumor antigen expression.
  • Cataloged tools for studying these antigens.

Conclusions:

  • Sialyltransferases are key players in cancer-associated sialylation.
  • Understanding their regulation is crucial for cancer diagnostics and therapeutics.
  • Developed tools aid in pathological sample analysis.