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Linking atherosclerosis to Alzheimer's disease: focus on biomarkers

Enzo Emanuele1, Valentina Martinelli, Vera Abbiati

  • 1Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy. enzo.em@libero.it

Frontiers in Bioscience (Elite Edition)
|December 29, 2011
PubMed

Insights

Biomarkers for atherosclerosis are altered in Alzheimer's disease (AD) patients. Studying these vascular biomarkers may reveal AD pathophysiology and progression mechanisms.

Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder linked to vascular factors.
  • Biomarkers for atherosclerosis and neurodegeneration are gaining significant research interest.
  • Altered levels of atherosclerotic vascular disease biomarkers have been reported in AD patients.

Purpose of the Study:

  • To review clinical studies on atherosclerosis/vascular disease biomarkers in AD patient serum/plasma.
  • To highlight future research directions in this field.
  • To explore how these biomarkers can elucidate AD pathophysiology.

Main Methods:

  • Systematic review of clinical studies.
  • Analysis of serum/plasma biomarker data in Alzheimer's disease patients.
  • Literature search for studies assessing atherosclerosis biomarkers in AD.

Main Results:

  • Numerous studies indicate altered levels of atherosclerotic biomarkers in AD.
  • Evidence suggests a significant link between vascular disease and Alzheimer's disease.
  • Specific biomarkers show promise in understanding disease mechanisms.

Conclusions:

  • Investigating atherosclerosis biomarkers in AD is crucial for understanding disease mechanisms.
  • This research can identify key components of AD pathophysiology.
  • Future studies should focus on the role of vascular biomarkers in AD progression.

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