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BNP and iNOS in decompensated chronic heart failure: a linear correlation
Lorenza Speranza1, Sara Franceschelli, Graziano Riccioni
1Department of Human Movement Sciences ,University G. D'Annunzio, Chieti Italy. l.speranza@unich.it
Frontiers in Bioscience (Elite Edition)
|December 29, 2011
Summary
Inflammatory mediators like inducible nitric oxide synthase (iNOS) are elevated in decompensated chronic heart failure (DCHF). This study found a significant linear correlation between iNOS activity and Brain Natriuretic Peptide (BNP) levels in DCHF patients.
Area of Science:
- Cardiology
- Immunology
- Biochemistry
Background:
- Heart Failure (HF) involves inflammatory mediators that worsen disease progression.
- Elevated Brain Natriuretic Peptide (BNP) levels in HF indicate poor prognosis.
- Inducible nitric oxide synthase (iNOS) plays a role in inflammatory processes.
Purpose of the Study:
- To assess inducible nitric oxide synthase (iNOS) expression and activity in peripheral blood mononuclear cells (PBMCs) of decompensated chronic heart failure (DCHF) patients.
- To investigate a potential linear correlation between iNOS and plasma BNP levels in DCHF.
- To compare iNOS and BNP levels between DCHF patients and a control group.
Main Methods:
- Evaluation of 35 male patients upon admission, including c-reactive protein testing to rule out acute inflammation.
- Inclusion of 20 DCHF patients exhibiting characteristic symptoms, reduced left ventricular ejection fraction (LVEF), and increased systolic pulmonary artery pressure (PAPs).
- Measurement of iNOS expression and activity in PBMCs, alongside plasma BNP levels, for comparison between DCHF patients and controls.
Main Results:
- Significantly higher iNOS expression and activity were observed in DCHF patients compared to the control group.
- Plasma BNP levels were significantly elevated in DCHF patients relative to controls.
- A significant linear correlation was established between iNOS activity and plasma BNP levels in DCHF patients.
Conclusions:
- Inducible nitric oxide synthase (iNOS) is upregulated in decompensated chronic heart failure (DCHF).
- Plasma Brain Natriuretic Peptide (BNP) levels are elevated in DCHF.
- iNOS activity demonstrates a significant linear correlation with BNP levels in DCHF, suggesting a potential link between inflammation and cardiac strain markers.
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