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Fibrosis: is it a coactivator disease?
Asish K Ghosh1, Douglas E Vaughan
1Feinberg Cardiovascular Research Institute, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. a-ghosh2@northwestern.edu
Frontiers in Bioscience (Elite Edition)
|December 29, 2011
Summary
The acetyltransferase p300 (ATp300) epigenetically regulates collagen synthesis, impacting fibrosis. Understanding ATp300’s role in matrix remodeling is crucial for treating fibrotic diseases.
Area of Science:
- Epigenetics
- Molecular Biology
- Pathology
Background:
- Fibrosis involves excessive extracellular matrix (ECM) accumulation disrupting tissue homeostasis.
- Epigenetic regulators, including acetyltransferases and microRNAs, influence ECM gene expression.
- The acetyltransferase p300 (ATp300) is a key epigenetic regulator involved in cellular processes and development.
Purpose of the Study:
- To review the significant roles of ATp300 in the epigenetic regulation of collagen synthesis and ECM deposition.
- To discuss the impact of ATp300 on matrix remodeling and tissue fibrogenesis.
- To explore the roles of acetyltransferases, deacetylases, and their inhibitors in epigenetic regulation of fibrosis.
Main Methods:
- Literature review focusing on ATp300's function in epigenetic regulation.
- Analysis of studies investigating the role of histone acetyltransferases (KAT) in gene expression.
- Examination of research on coactivator activity and associated diseases.
Main Results:
- ATp300 plays a critical role in the epigenetic control of collagen synthesis and ECM deposition.
- Dysregulation of ATp300 activity is linked to various diseases, including fibrotic conditions.
- Epigenetic mechanisms involving acetyltransferases and deacetylases are central to matrix remodeling and fibrogenesis.
Conclusions:
- ATp300 is a significant epigenetic regulator influencing collagen synthesis, matrix deposition, and tissue fibrogenesis.
- Understanding the interplay between ATp300, matrix remodeling, and fibrosis offers therapeutic targets.
- Further research into epigenetic modulators like ATp300 is vital for combating fibrotic diseases.
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