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Isolated Lung Perfusion System in the Rabbit Model
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Isolated lung perfusion.

Marcelo Cypel1, Shaf Keshavjee

  • 1Division of Thoracic Surgery and Lung Transplant Program. Toronto General Hospital, 190 Elizabeth St. RFE 1-408, Toronto, ON, M5G 2C4, Canada.

Frontiers in Bioscience (Elite Edition)
|December 29, 2011
PubMed
Summary
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Isolated lung perfusion (ILP) techniques, including Ex vivo Lung Perfusion (EVLP) and in vivo lung perfusion (IVLP), are advancing lung transplantation and oncology treatments. These methods assess donor lungs and deliver targeted chemotherapy for lung metastases.

Area of Science:

  • Cardiovascular and Respiratory System Physiology
  • Thoracic Surgery Innovations
  • Pulmonary Medicine and Oncology

Background:

  • Isolated lung perfusion (ILP) is a technique historically used in animal models for physiological studies.
  • ILP applications have expanded to clinical settings in lung transplantation and thoracic oncology.
  • The lung's isolated vasculature allows for targeted interventions.

Purpose of the Study:

  • To review the rationale, technical aspects, and clinical experience of Ex vivo Lung Perfusion (EVLP) and in vivo lung perfusion (IVLP).
  • To highlight the utility of ILP in assessing donor lung integrity and treating pulmonary metastases.
  • To provide a perspective on the future applications of EVLP and IVLP.

Main Methods:

  • Review of existing literature on ILP techniques, focusing on EVLP and IVLP.

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Last Updated: May 26, 2026

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  • Analysis of experimental and clinical data regarding the application of ILP in transplantation and oncology.
  • Discussion of the technical considerations and physiological principles underlying ILP.

    • Main Results:

    • EVLP is utilized to evaluate donor lung viability and offers potential for ex vivo organ repair.
    • IVLP enables targeted delivery of high-dose chemotherapy for pulmonary metastatic disease.
    • Both EVLP and IVLP demonstrate significant potential in their respective clinical fields.

    Conclusions:

    • EVLP and IVLP represent significant advancements in lung transplantation and thoracic oncology.
    • These perfusion techniques offer promising avenues for improved patient outcomes and organ utilization.
    • Further research and clinical implementation are expected to expand the role of ILP.