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Physiological and pathophysiological functions of SOCE in the immune system
1Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA.
Frontiers in Bioscience (Elite Edition)
|December 29, 2011
Summary
Store-operated calcium entry (SOCE) is vital for immune cell function, mediated by ORAI and STIM proteins. Defects in SOCE lead to immune disorders, highlighting its critical role in immune responses.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Calcium signals are essential for immune cell effector functions.
- Store-operated calcium entry (SOCE) is the primary mechanism for increasing intracellular calcium in immune cells.
- SOCE is mediated by ORAI proteins and stromal interaction molecules (STIM).
Purpose of the Study:
- To review recent advances in understanding SOCE in immune cells.
- To emphasize immune dysregulation resulting from SOCE defects.
- To highlight the roles of ORAI and STIM proteins in immune cell function.
Main Methods:
- Review of existing literature on SOCE in immune cells.
- Analysis of patient data with mutations in STIM1 and ORAI1 genes.
- Examination of studies involving gene-targeted mice.
Main Results:
- SOCE, mediated by ORAI/STIM proteins, is crucial for the function of various immune cells.
- Mutations in STIM1 and ORAI1 genes cause immunodeficiency and autoimmunity.
- Defects in SOCE lead to significant immune dysregulation.
Conclusions:
- ORAI/STIM-dependent SOCE is indispensable for normal immune responses.
- Understanding SOCE defects provides insights into immune disorders.
- Targeting SOCE pathways may offer therapeutic strategies for immune diseases.
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