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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Related Experiment Video

Updated: May 26, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

Structure and function of the solid tumor niche.

Elisabeth A Pedersen1, Yusuke Shiozawa, Anjali Mishra

  • 1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA.

Frontiers in Bioscience (Scholar Edition)
|December 29, 2011
PubMed
Summary
This summary is machine-generated.

The bone marrow microenvironment (BMM) may function as a niche for both hematopoietic stem cells (HSCs) and solid tumor cells. Understanding the HSC niche offers insights into the BMM

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A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
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A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

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Last Updated: May 26, 2026

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
08:32

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
07:20

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

Published on: February 28, 2020

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
16:18

Microfluidic Device for Recreating a Tumor Microenvironment in Vitro

Published on: November 20, 2011

Area of Science:

  • * Hematology and Oncology
  • * Cancer Metastasis Research
  • * Stem Cell Biology

Background:

  • * The hematopoietic stem cell (HSC) niche in the bone marrow microenvironment (BMM) is well-studied.
  • * The BMM's role as a niche for solid metastatic tumor cells is a recent area of investigation.
  • * Shared structural and functional components suggest potential overlap between HSC and tumor niches.

Purpose of the Study:

  • * To explore the concept of the bone marrow microenvironment (BMM) as a niche for solid metastatic tumor cells.
  • * To investigate the similarities between the hematopoietic stem cell (HSC) niche and the solid tumor niche.
  • * To leverage current understanding of the HSC niche to better define the solid tumor niche.

Main Methods:

  • * Comparative analysis of the structural and functional components of the HSC niche and the solid tumor niche.
  • * Review of existing literature on osteoblast function in both HSC regulation and tumor cell processes.
  • * Synthesis of knowledge regarding niche-mediated regulation of cellular processes.

Main Results:

  • * The osteoblast is identified as a critical component in both HSC and solid tumor niches.
  • * Osteoblasts regulate key cellular processes including homing, migration, growth, survival, quiescence, and dormancy in both contexts.
  • * Significant overlap exists in the regulatory roles of the HSC niche and the potential solid tumor niche.

Conclusions:

  • * The bone marrow microenvironment (BMM) may serve as a shared niche for both HSCs and metastatic tumor cells.
  • * Understanding the HSC niche provides a framework for defining the solid tumor niche.
  • * Further research into niche regulation in the BMM could reveal new therapeutic targets for metastatic disease.