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The future of autoimmunity.

Yehuda Shoenfeld1

  • 1The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel. shoenfel@post.tau.ac.il

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Summary
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Despite advances in understanding autoimmunity, significant knowledge gaps remain. This special issue addresses critical clinical autoimmunity issues, aiming to improve patient care by exploring complex factors like genetics, environment, and microbiology.

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Area of Science:

  • Immunology and Epidemiology
  • Autoimmune Disease Pathogenesis
  • Clinical Autoimmunity

Background:

  • Significant progress has been made in understanding autoimmunity through epidemiology, immunology, disease classification, and therapeutics.
  • However, substantial gaps persist in understanding genetic susceptibility, gene-environment interactions, and preclinical disease tolerance induction.
  • Key areas needing further investigation include host susceptibility, responses to biologic agents, and disease clustering.

Discussion:

  • The rising incidence of autoimmune diseases in Western societies warrants further epidemiological study.
  • The intricate relationships between the microbiome, vaccination, antibiotic use, environmental pollutants, and nanoparticles in autoimmunity induction and progression require exploration.
  • This special issue focuses on less-discussed clinical aspects of autoimmunity.

Key Insights:

  • Autoimmunity research has advanced significantly but faces persistent voids in crucial areas.
  • Understanding the interplay of genetics, environment, and lifestyle factors is critical for unraveling autoimmune disease etiology.
  • Addressing these voids is essential for developing more effective diagnostic and therapeutic strategies.

Outlook:

  • Future research should prioritize investigating the complex interplay of environmental factors and host susceptibility in autoimmune diseases.
  • Developing novel strategies for inducing tolerance in preclinical stages and managing responses to biologic therapies is crucial.
  • This special issue aims to stimulate discussion and advance patient care by highlighting underexplored clinical autoimmunity challenges.