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Application of Membrane and Cell Wall Selective Fluorescent Dyes for Live-Cell Imaging of Filamentous Fungi
Published on: November 28, 2019
Sporothrix schenckii Cell Wall Peptidorhamnomannans
1Laboratório de Micologia Celular e Proteômica, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro Rio de Janeiro, Brazil.
Frontiers in Microbiology
|December 29, 2011
Summary
This review clarifies Sporothrix schenckii cell wall components, focusing on peptidorhamnomannans and surface antigens. Understanding these structures aids in developing diagnostic tools for sporotrichosis.
Area of Science:
- Biochemistry
- Mycology
- Immunology
Background:
- Sporothrix schenckii is a fungus causing sporotrichosis in humans and felines.
- The fungal cell wall plays a crucial role in host-pathogen interactions.
- Peptidorhamnomannans are key components of the S. schenckii cell wall.
Purpose of the Study:
- To elucidate critical biochemical aspects of Sporothrix schenckii cell wall peptidorhamnomannans.
- To review surface molecules involved in host interaction, including antigens and gp70 adhesin.
- To discuss other structural glycoconjugates on the fungal cell surface.
Main Methods:
- Literature review of biochemical and structural studies on S. schenckii.
- Analysis of cell wall composition and surface molecule characterization.
- Exploration of immunochemical approaches for diagnosis.
Main Results:
- Detailed description of S. schenckii cell wall peptidorhamnomannans.
- Identification of surface antigens and gp70 adhesin as critical for host interaction.
- Characterization of various fungal cell surface glycoconjugates.
Conclusions:
- Understanding the fine structure of S. schenckii surface carbohydrate epitopes is essential.
- This knowledge facilitates the development of non-invasive immunochemical diagnostic methods for sporotrichosis.
- The review highlights the importance of cell wall biochemistry in fungal pathogenesis and diagnostics.
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