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Published on: September 15, 2018
MicroRNA dysregulation in schizophrenia
Natalie J Beveridge1, Murray J Cairns
1Faculty of Health and the Hunter Medical Research Institute, School of Biomedical Sciences and Pharmacy, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia.
Neurobiology of Disease
|December 31, 2011
Summary
MicroRNAs (miRNAs) are key regulators in brain development and function. Altered miRNA levels and machinery in schizophrenia suggest potential diagnostic biomarkers and therapeutic targets.
Area of Science:
- Neuroscience
- Genetics
- Molecular Biology
Background:
- Schizophrenia involves complex neural circuitry and synaptic dysfunction.
- Posttranscriptional gene regulation by microRNAs (miRNAs) is crucial for neural network development and maintenance.
Purpose of the Study:
- To review evidence on the role of miRNAs in schizophrenia pathophysiology.
- To explore miRNAs as potential diagnostic biomarkers and therapeutic targets for schizophrenia.
Main Methods:
- Review of current literature on miRNA expression and function in schizophrenia.
- Analysis of studies investigating miRNA biogenesis machinery and genetic/epigenetic factors in schizophrenia.
Main Results:
- Mature miRNA levels are altered in the brain and peripheral blood mononuclear cells (PBMCs) of schizophrenia patients.
- Evidence suggests genetic mutations and epigenetic influences on miRNA genes and biogenesis machinery in schizophrenia.
Conclusions:
- miRNA dysregulation significantly contributes to schizophrenia pathophysiology.
- Altered miRNA expression in PBMCs may serve as diagnostic biomarkers.
- miRNA-related pathways represent promising targets for novel schizophrenia therapeutics.
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