A review of post-GWAS studies in schizophrenia

Advances in genotyping and DNA sequencing have led to the discovery of many schizophrenia-associated loci and new and unexpected pathophysiological mechanisms. Despite this tremendous progress, only a small proportion of the Schizophrenia risk can be linked to the biological or physiological mechanisms. This has led to the development of many post-GWAS methods to further explore the mechanisms behind phenotypes and diseases. In this review we will give an overview of the current computational and experimental approaches that can convert the GWAS results into insights into the underlying causal architecture of Schizophrenia.