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Virtual active touch using randomly patterned intracortical microstimulation.

Joseph E O'Doherty1, Mikhail A Lebedev, Zheng Li

  • 1Department of Physiology and the W. M. Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA. joeyo@phy.ucsf.edu

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
|December 31, 2011
PubMed
Summary
This summary is machine-generated.

Temporal patterns of intracortical microstimulation (ICMS) can simulate tactile sensation for neuroprosthetics. Monkeys could distinguish patterned ICMS, improving movement reconstruction in sensorimotor cortex recordings.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Rehabilitation Engineering

Background:

  • Intracortical microstimulation (ICMS) shows potential for restoring somatosensory feedback in neuroprosthetic systems.
  • Encoding tactile sensations via temporal, spatial, or spatiotemporal ICMS patterns is feasible.
  • The efficacy of temporal ICMS patterns for artificial tactile sensation during active exploration remains unclear.

Purpose of the Study:

  • To investigate the applicability of temporal ICMS patterns for artificial tactile sensation.
  • To determine the minimum discriminable difference between temporally modulated ICMS patterns.
  • To assess the impact of ICMS artifacts on neural recordings during active exploration tasks.

Main Methods:

  • Rhesus monkeys were trained in an active exploration task.
  • Monkeys discriminated periodic pulse-trains of ICMS from aperiodic pulse trains with distorted periodicity.
  • Neuronal population activity in the sensorimotor cortex was recorded concurrently with ICMS delivery.

Main Results:

  • Monkeys successfully distinguished periodic pulse trains from aperiodic pulse trains with coefficients of variation of 0.25 or greater.
  • Reconstruction of movement kinematics improved when ICMS-affected recording intervals were excluded from analysis.
  • These findings support the use of temporally patterned ICMS for tactile feedback.

Conclusions:

  • Temporally patterned ICMS can effectively simulate tactile sense for neuroprosthetic applications.
  • The ability to discriminate temporal ICMS patterns is crucial for effective sensory feedback.
  • Minimizing ICMS artifacts in neural recordings enhances the analysis of sensorimotor cortex activity.