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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: May 26, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

Adipose stem cell-based soft tissue regeneration.

Brian J Philips1, Kacey G Marra, J Peter Rubin

  • 1University of Pittsburgh, Division of Plastic Surgery, Department of Surgery, Pittsburgh, PA 15261, USA.

Expert Opinion on Biological Therapy
|January 3, 2012
PubMed
Summary
This summary is machine-generated.

Adipose-derived stem cells (ASCs) show promise for soft tissue reconstruction due to their regenerative potential. Further clinical studies are needed to confirm their safety and efficacy in enhancing fat graft retention.

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Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
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Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
10:43

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Published on: March 5, 2019

Related Experiment Videos

Last Updated: May 26, 2026

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate
11:31

Repair of a Critical-sized Calvarial Defect Model Using Adipose-derived Stromal Cells Harvested from Lipoaspirate

Published on: October 31, 2012

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model
08:06

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells
10:43

Differentiation Capacity of Human Aortic Perivascular Adipose Progenitor Cells

Published on: March 5, 2019

Area of Science:

  • Regenerative Medicine
  • Soft Tissue Engineering
  • Stem Cell Biology

Background:

  • Adipose-derived stem cells (ASCs) are a popular adult stem cell source for regenerative medicine.
  • ASCs offer advantages like abundant autologous supply and multi-lineage potential.
  • Preclinical and early clinical data support ASCs in soft tissue applications.

Purpose of the Study:

  • To review clinical and preclinical data on ASCs for soft tissue reconstruction.
  • To examine experimental models and methodologies used in ASC research.
  • To discuss future directions for improving reconstructive therapies.

Main Methods:

  • Review of published clinical and preclinical studies on ASCs.
  • Focus on experimental models and methodologies for soft tissue reconstruction.
  • Analysis of data regarding ASC applications in regenerative medicine.

Main Results:

  • ASCs demonstrate potential in enhancing fat graft retention.
  • ASCs may facilitate minimally invasive reconstructive treatments.
  • Current clinical applications are being reported, but require further validation.

Conclusions:

  • Standardization of ASC harvesting and processing is needed.
  • Long-term results from clinical studies are essential.
  • Well-controlled clinical trials are required to establish ASC safety and efficacy.