Related Experiment Video
Updated: May 26, 2026
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Low-dose GnRH antagonist protocol is as effective as the long GnRH agonist protocol in unselected patients undergoing
Shang-Yu Huang1, Hong-Yuan Huang, Hsing-Tse Yu
1Department of Obstetrics and Gynecology, Linkou Medical Center, Taoyuan, Taiwan.
Objective:
The present retrospective and controlled comparative study was designed to evaluate the pregnancy rate achieved using a modified, fixed, multiple-dose 0.125mg gonadotropin-releasing hormone (GnRH) antagonist protocol with the long GnRH agonist protocol as the control group.
Materials And Methods:
One hundred and twenty unselected women between 30 and 40 years of age, in their first cycle of IVF/ICSI, with a baseline follicle-stimulating hormone (FSH) <10 IU and an antral follicle count >3 were assigned into two groups: (1) the study group received 0.125mg of cetrorelix daily starting on Day 6 of stimulation; and (2) the control group received leuprolide daily starting in the mid-luteal phase of the preceding cycle. Both groups were given a flexible dose of recombinant FSH for stimulation. An ongoing pregnancy rate of more than 12 weeks was the primary outcome measure of the study.
Results:
Primary and secondary outcomes were comparable in both groups. A shorter duration of stimulation, a lower dosage of recombinant FSH consumption and a thinner endometrium on the day of human chorionic gonadotropin administration were all observed in the GnRH antagonist group.
Conclusion:
A dosage of 0.125mg GnRH antagonist protocol was effective for these unselected patients during IVF/ET.
