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Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
Published on: November 20, 2018
Adiabatic pulse preparation for imaging iron oxide nanoparticles
Steven S Harris1, Hui Mao, Xiaoping P Hu
1Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Magnetic Resonance in Medicine
|January 4, 2012
Summary
This study introduces a new imaging method using superparamagnetic iron oxide nanoparticles. The technique offers quantitative iron concentration imaging, unaffected by magnetic field variations.
Area of Science:
- Magnetic Resonance Imaging
- Nanotechnology
- Biomedical Engineering
Background:
- Superparamagnetic iron oxide nanoparticles (SPIONs) alter local magnetic fields.
- Developing quantitative imaging methods for SPIONs is crucial for biomedical applications.
Purpose of the Study:
- To introduce a novel contrast generation method for SPIONs using adiabatic pulses.
- To evaluate the linearity and sensitivity of the method with varying iron concentrations.
Main Methods:
- Utilized adiabatic preparation pulses and exploited the failure of adiabatic conditions around SPIONs.
- Acquired images with and without the adiabatic pulse, calculating the difference image.
- Tested adiabatic full passage and adiabatic zero passage pulses for contrast generation.
Main Results:
- Contrast in difference images showed linear dependence on iron concentration up to 1 mM with adiabatic full passage.
- Adiabatic zero passage pulse demonstrated higher sensitivity and maintained linear dependence to 0.1 mM.
- The technique proved insensitive to magnetization transfer and B(0) inhomogeneity.
Conclusions:
- The novel method provides quantitative imaging of iron concentration.
- Its linearity and insensitivity to magnetic field fluctuations make it suitable for SPION imaging.
