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Related Concept Videos

Pressure Relationships in Thoracic Cavity01:24

Pressure Relationships in Thoracic Cavity

Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Pneumothorax II: Pathophysiology01:08

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...
Variation of Atmospheric Pressure01:18

Variation of Atmospheric Pressure

Change in atmospheric pressure with height is particularly interesting. The decrease in atmospheric pressure with increasing altitude is due to the decreasing gravitational force per unit area as we move away from the surface of the earth.
Assuming the air temperature is constant at a given altitude and that the ideal gas law of thermodynamics describes the atmosphere to a good approximation, one can find the variation of atmospheric pressure with height.
Let p(y) be the atmospheric pressure at...
Definition and Measurement of Pressure: Atmospheric Pressure, Barometer, and Manometer02:57

Definition and Measurement of Pressure: Atmospheric Pressure, Barometer, and Manometer

Gas pressure is caused by force exerted by gas molecules colliding with the surfaces of objects. Although the force of each collision is very small, any surface of an appreciable area experiences a large number of collisions in a short time, which can result in high pressure.
Physiological Control of Respiration01:23

Physiological Control of Respiration

Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

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Updated: May 26, 2026

Measurement of the Pressure-volume Curve in Mouse Lungs
09:49

Measurement of the Pressure-volume Curve in Mouse Lungs

Published on: January 27, 2015

Subatmospheric pressure therapy: basic science review.

Benjamin C Wood1, Joseph A Molnar

  • 1Department of Plastic and Reconstructive Surgery, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

Journal of Surgical Orthopaedic Advances
|January 5, 2012
PubMed
Summary
This summary is machine-generated.

Subatmospheric pressure (SAP) therapy significantly improves wound healing by reducing edema, clearing bacteria, and increasing blood flow. Emerging evidence suggests micro-deformation and biochemical regulation also contribute to its effectiveness.

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Area of Science:

  • Wound Healing Research
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Subatmospheric pressure (SAP) therapy, exemplified by the Vacuum Assisted Closure (V.A.C.) device, is a prominent treatment for acute and chronic wounds.
  • Historically, SAP therapy's benefits were attributed to edema reduction, bacterial clearance, and enhanced wound bed perfusion.
  • Recent research suggests additional mechanisms involving micro-deformation and biochemical mediator regulation contribute to improved wound healing outcomes.

Purpose of the Study:

  • To review the established and emerging mechanisms of Subatmospheric Pressure (SAP) therapy in wound healing.
  • To highlight the role of micro-deformation and biochemical regulation in SAP therapy's efficacy.
  • To identify areas for future research into the precise workings of SAP therapy.

Main Methods:

  • Literature review of studies on Subatmospheric Pressure (SAP) therapy.
  • Analysis of clinical outcomes associated with SAP wound treatment systems.
  • Examination of recent investigations into the cellular and molecular effects of SAP therapy.

Main Results:

  • SAP therapy demonstrates significant improvements in healing for various wound types.
  • Established benefits include edema reduction, bacterial load decrease, and improved perfusion.
  • Novel findings indicate micro-deformation and modulation of biochemical mediators are key contributors.

Conclusions:

  • SAP therapy is a well-established and effective wound treatment modality.
  • The mechanisms of action are multifaceted, involving mechanical and biological processes.
  • Further research is warranted to fully elucidate the complex pathways involved in SAP-mediated wound healing.