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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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Related Experiment Video

Updated: May 26, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Published on: August 15, 2016

[Novel approach of cyclodextrin-based pharmaceutical formulation].

Kaneto Uekama1

  • 1Sojo University, 4-22-1 Ikeda, Kumamoto 860-0082, Japan. uekama@ph.soju-u.ac.jp

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|January 5, 2012
PubMed
Summary

Cyclodextrins (CyDs) enhance drug delivery by forming inclusion complexes. Novel CyD derivatives improve drug absorption, release profiles, targeting, and solid-state properties for advanced pharmaceutical formulations.

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Area of Science:

  • Supramolecular Chemistry
  • Pharmaceutical Sciences
  • Materials Science

Context:

  • Cyclodextrins (CyDs), including alpha-, beta-, and gamma-CyDs, are cyclic oligosaccharides with established roles in drug formulation.
  • Gamma-cyclodextrin (γ-CyD) is particularly noted for its bioadaptability and ability to form inclusion complexes, improving drug properties.
  • Recent advancements include the development of diverse CyD derivatives (hydrophilic, hydrophobic, amphipathic, anionic) for sophisticated drug delivery systems.

Purpose:

  • To review recent findings on the combined use of γ-CyD and functional ingredients in drug delivery.
  • To highlight the capabilities of CyD derivatives in enhancing drug absorption, controlling release kinetics, and enabling targeted drug delivery.
  • To explore the application of specific CyD derivatives, like 2-hydroxypropyl-β-CyD (HP-β-CyD), in creating novel pharmaceutical formulations, including nanoparticles.

Summary:

  • Investigates the synergistic effects of γ-CyD with functional ingredients to enhance drug absorption, modulate release rates, and achieve site-specific delivery.
  • Details the utility of hydroxyalkylated CyDs (e.g., HP-β-CyD) in forming hydrophilic nanoparticles for advanced drug formulations.
  • Examines the role of amphipathic CyDs (e.g., DM-β-CyD, HB-β-CyD) in controlling drug crystallization and polymorphic transitions, aiding in the isolation of metastable polymorphs.

Impact:

  • Provides insights into optimizing drug delivery systems through strategic use of natural and modified cyclodextrins.
  • Demonstrates the potential of CyD-based formulations to overcome challenges related to drug solubility, stability, and bioavailability.
  • Offers a comprehensive understanding of the pharmaceutical applications and limitations of cyclodextrins, guiding future drug development strategies.