Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Exercise Stress Test01:26

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be met...
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is it time to implement a hemorheology passport in sickle cell disease?

Blood cells, molecules & diseases·2026
Same author

Long-Distance Trail Running Induces Inflammatory-Associated Protein, Lipid, and Purine Oxidation in Red Blood Cells.

Blood. Red cells & iron·2026
Same author

Heatstroke in a tropical environment: A series of 9 cases over 18 days in Guadeloupe.

Archives of environmental & occupational health·2026
Same author

Should we longitudinally monitor blood viscosity in patients with sickle cell anemia?

Blood cells, molecules & diseases·2026
Same author

In vitro effects of voxelotor on red blood cell senescence and rheological behavior in sickle cell anemia.

Blood cells, molecules & diseases·2026
Same author

Genetic, clinical, and biological risk factors associated with optic nerve thinning in sickle cell disease.

Eye (London, England)·2026

Related Experiment Video

Updated: May 26, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Exercise limitation, exercise testing and exercise recommendations in sickle cell anemia.

Philippe Connes1, Roberto Machado, Olivier Hue

  • 1Laboratory ACTES, Department of Physiology, University of the French West Indies, Pointe a Pitre, Guadeloupe, French West Indies. pconnes@yahoo.fr

Clinical Hemorheology and Microcirculation
|January 5, 2012
PubMed
Summary
This summary is machine-generated.

Sickle cell anemia (SCA) patients experience exercise limitations due to anemia and complications. Current exercise guidance for SCA lacks robust evidence, emphasizing symptom-limited activity and general precautions.

More Related Videos

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Related Experiment Videos

Last Updated: May 26, 2026

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
07:26

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

Published on: October 17, 2018

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Area of Science:

  • Hematology
  • Exercise Physiology
  • Genetics

Background:

  • Sickle cell anemia (SCA) is an inherited blood disorder stemming from a genetic mutation affecting hemoglobin solubility.
  • Deoxygenated hemoglobin polymerization in SCA leads to red blood cell sickling, hemolysis, vaso-occlusion, and organ damage.
  • Exercise can trigger sickling episodes and exercise limitation in SCA patients due to anemia or chronic complications.

Purpose of the Study:

  • To review the cardiorespiratory responses of SCA patients during exercise.
  • To discuss current exercise recommendations and limitations in SCA management.
  • To highlight principles for exercise prescription and rehabilitation in SCA.

Main Methods:

  • Review of existing literature on cardiorespiratory responses during exercise tests in SCA patients.
  • Analysis of factors contributing to exercise limitation in SCA.
  • Synthesis of principles for exercise prescription and rehabilitation.

Main Results:

  • Limited studies exist on detailed cardiorespiratory responses during maximal exercise or walk tests in SCA.
  • Exercise limitation in SCA is multifactorial, including anemia and chronic organ damage.
  • Current advice focuses on symptom-limited exercise, hydration, and avoiding environmental triggers and trauma.

Conclusions:

  • There is a significant lack of evidence-based guidelines for exercise prescription in SCA.
  • Symptom-limited exercise and general precautions are currently recommended for SCA patients.
  • Further research is needed to establish safe and effective exercise programs for SCA rehabilitation.