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Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice
08:43

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

Published on: January 31, 2020

[Autoimmunity to glycolytic enzyme in rheumatoid arthritis]

Isao Matsumoto1, Keiichi Iwanami, Yoko Tanaka

  • 1Division of Clinical Immunology, Graduate School of Comprehensive Human Science, University of Tsukuba, Japan.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology
|January 5, 2012
PubMed

Insights

Rheumatoid arthritis (RA) prognosis improves with biologics. Glucose-6-phosphate isomerase, a glycolytic enzyme, shows arthritogenic potential relevant to RA pathogenesis.

Area of Science:

  • Immunology and Rheumatology
  • Molecular Biology
  • Biochemistry

Context:

  • Rheumatoid arthritis (RA) patient outcomes have improved with targeted biologics (anti-TNFα, anti-IL-6, anti-co-stimulatory molecules).
  • Anti-CD20 antibodies demonstrate clear therapeutic benefits in RA in US and European clinical practice.
  • Rheumatoid factor and anti-citrullinated protein antibodies are key RA markers, but their pathological roles remain unclear.

Purpose:

  • To explore the pathogenic relevance of the glycolytic enzyme glucose-6-phosphate isomerase (GPI) in rheumatoid arthritis.
  • To investigate GPI's role as an arthritogenic factor, building on evidence from mouse models.

Summary:

  • Biologics targeting TNFα, IL-6, and co-stimulatory molecules have improved RA prognosis.
  • Glucose-6-phosphate isomerase (GPI), a glycolytic enzyme, has been confirmed as arthritogenic in murine models.
  • This study discusses the pathogenic relevance of GPI in rheumatoid arthritis, complementing known disease markers.

Impact:

  • Highlights a potential novel therapeutic target (GPI) for rheumatoid arthritis.
  • Advances understanding of RA pathogenesis beyond established autoantibodies.
  • Provides a molecular target for future RA drug development and research.

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