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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Published on: December 6, 2016

Obstructive sleep apnea linked to wake-up strokes.

Sun-Wung Hsieh¹, Chiou-Lian Lai, Ching-Kuan Liu

¹Department of Neurology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan.

Journal of Neurology

|January 5, 2012

Summary

This summary is machine-generated.

Obstructive sleep apnea (OSA) is linked to wake-up stroke (WUS) in mild to moderate ischemic stroke patients. Severe OSA independently predicts WUS, highlighting its importance in stroke risk assessment.

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Area of Science:

Neurology
Sleep Medicine
Cardiovascular Research

Background:

Obstructive sleep apnea (OSA) is a known risk factor for ischemic stroke.
The specific association between OSA and wake-up stroke (WUS) remains under-investigated.

Purpose of the Study:

To investigate the relationship between obstructive sleep apnea and wake-up stroke in patients with mild to moderate ischemic stroke.

Main Methods:

Prospective study of 71 mild to moderate ischemic stroke patients.
Sleep respiratory studies conducted 3-14 days post-stroke.
Comparison of demographic, sleep, cardiovascular, and stroke-related data between WUS and non-WUS groups.

Main Results:

36.6% of patients experienced WUS.
WUS patients exhibited higher apnea-hypopnea index and obstructive apnea index, with lower mean blood oxygen saturation.
Severe sleep-disordered breathing (AHI ≥30) was the sole independent predictor of WUS (OR 6.065).

Conclusions:

Obstructive sleep apnea is a significant independent risk factor for wake-up stroke in mild to moderate ischemic stroke patients.
Clinical differentiation between WUS and non-WUS is challenging based on current data.
Findings underscore the importance of evaluating OSA in stroke patients, particularly those with WUS.