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Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases

Brian Henderson1, A Graham Pockley

  • 1Department of Microbial Diseases, UCL-Eastman Dental Institute, University College London, London, UK. Brian.Henderson@ucl.ac.uk

Cell Stress & Chaperones
|January 5, 2012
PubMed

Insights

Secreted cell stress proteins impact cardiovascular health. These proteins can signal, reduce inflammation, or promote inflammation, influencing cardiovascular disease dynamics.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Stress Physiology

Background:

  • The cardiovascular system is highly susceptible to stress.
  • Elevated intracellular cell stress proteins in the heart confer protection.
  • Emerging evidence highlights the role of secreted cell stress proteins in cardiovascular function.

Purpose of the Study:

  • To explore the multifaceted roles of secreted cell stress proteins in cardiovascular tissues.
  • To understand how these proteins function as signaling molecules, anti-inflammatory agents, or pro-inflammatory mediators.
  • To conceptualize secreted cell stress proteins as a dynamic network influencing cardiovascular health and disease.

Main Methods:

  • Review of existing literature on cell stress proteins and cardiovascular function.
  • Analysis of the known functions of specific secreted proteins like protein disulphide isomerase, Hsp27, and Hsp60.
  • Conceptual framework development for secreted cell stress proteins as a dynamic system.

Main Results:

  • Secreted cell stress proteins exhibit diverse functions: homeostatic signaling, anti-inflammatory effects, and pro-inflammatory actions.
  • Specific examples include protein disulphide isomerase (homeostasis), Hsp27 (anti-inflammatory), and Hsp60 (pro-inflammatory).
  • The release rates and functions of these proteins vary across different cardiovascular diseases.

Conclusions:

  • Secreted cell stress proteins represent a dynamic network with the potential to both support and harm the cardiovascular system.
  • Understanding this network is crucial for comprehending cardiovascular disease pathogenesis.
  • Targeting these proteins may offer novel therapeutic strategies for cardiovascular conditions.

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