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Spectral electroretinography in thioridazine toxicity
V Godel1, A Loewenstein, M Lazar
1Department of Ophthalmology, Ichilov Hospital, Tel Aviv University Medical School, Israel.
Annals of Ophthalmology
|August 1, 1990
Summary
Thioridazine toxicity can impair electroretinogram (ERG) function, particularly to red light. Stopping the medication improved ERG amplitude in most patients, while increasing the dose worsened vision.
Area of Science:
- Ophthalmology
- Clinical Pharmacology
Background:
- Thioridazine is an antipsychotic medication with known ocular side effects.
- Electroretinography (ERG) assesses retinal function and is sensitive to drug-induced changes.
Observation:
- Three patients with thioridazine toxicity exhibited reduced ERG amplitudes, especially to red light stimuli.
- Two patients showed ERG improvement after discontinuing thioridazine therapy.
Findings:
- ERG amplitude reduction correlated with thioridazine toxicity.
- Increased thioridazine dosage led to further ERG deterioration across various light stimuli.
- Cessation of thioridazine therapy was associated with partial ERG recovery.
Implications:
- ERG can serve as a biomarker for thioridazine-induced retinal dysfunction.
- Monitoring ERG may be crucial for patients on long-term thioridazine treatment.
- These findings highlight the importance of dose management and therapeutic drug monitoring for thioridazine.