Focal cortical dysplasia. Clinical-radiological-pathological associations
I Pascual-Castroviejo1, J L Hernández-Moneo, M L Gutiérrez-Molina
1Servicio de Neurología Pediátrica, Hospital Universitario La Paz, Madrid, España. i.pcastroviejo@neurologia.e.telefonica.net
Neurologia (Barcelona, Spain)
|January 6, 2012
Summary
Early surgical extirpation of Taylor-type focal cortical dysplasia (FCD) can effectively treat drug-resistant focal seizures. Prompt identification and removal of FCD offer a high chance of seizure freedom in many patients.
Area of Science:
- Neurology
- Neurosurgery
- Histopathology
Background:
- Focal cortical dysplasia (FCD) is a brain malformation causing drug-resistant epilepsy.
- FCD presents with characteristic imaging and histological findings.
- Surgical treatment is often effective for FCD-related seizures.
Purpose of the Study:
- To evaluate the efficacy of surgical intervention for Taylor-type FCD.
- To assess seizure outcomes following FCD extirpation.
Main Methods:
- Retrospective study of 7 patients with MRI-confirmed FCD.
- Surgical extirpation of FCD and surrounding tissue.
- Histopathological analysis to confirm FCD type.
Main Results:
- 3 patients (girls) underwent early surgery with FCD extirpation.
- Histopathology confirmed Taylor-type FCD in operated patients.
- These 3 patients remained seizure-free for 3 years post-surgery without medication.
Conclusions:
- Taylor-type FCD is a significant cause of drug-resistant focal seizures.
- Timely surgical extirpation of FCD can lead to long-term seizure remission.
- Complete surgical removal of FCD is crucial for successful treatment outcomes.
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