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Update: Influenza A (H3N2)v transmission and guidelines - five states, 2011

    MMWR. Morbidity and Mortality Weekly Report
    |January 6, 2012
    PubMed

    Insights

    Twelve human infections with a novel influenza A (H3N2)v virus occurred in 2011. Most cases were children, with some lacking swine exposure, highlighting potential for human-to-human transmission.

    Area of Science:

    • Virology
    • Public Health
    • Epidemiology

    Background:

    • Influenza A (H3N2)v viruses are reassortant viruses with genes from different influenza strains.
    • Understanding the transmission and characteristics of novel influenza viruses is crucial for public health preparedness.

    Observation:

    • From August to December 2011, the CDC documented 12 human cases of influenza A (H3N2)v virus infection.
    • These cases were reported across five US states, with a majority (11 of 12) affecting children.

    Findings:

    • The identified influenza A (H3N2)v viruses possessed the matrix (M) gene from the influenza A (H1N1)pdm09 virus.
    • Notably, six of the 12 infected individuals had no documented recent exposure to swine.
    • Three patients required hospitalization, but all recovered fully.

    Implications:

    • The findings suggest a potential for human-to-human transmission of this reassortant influenza virus, even without direct swine contact.
    • This underscores the importance of ongoing surveillance for novel influenza viruses and their potential to cause outbreaks.
    • Further research is needed to understand the full public health impact and transmission dynamics of such reassortant influenza strains.

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