Related Experiment Video
Updated: May 26, 2026

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
Published on: December 15, 2023
Cyclin-dependent kinase inhibition with roscovitine: neuroprotection in acute ischemic stroke
1CHRU Brest, Hôpital de la Cavale Blanche, Département de Neurologie, Faculté de Médecine et des Sciences de la Santé, INSERM U-613 de Brest, Brest, France. serge.timsit@chu-brest.fr
Abstract:
Stroke is the third most common cause of mortality and the leading cause of disability in industrialized country. According to population based-studies, ischemic stroke accounts for 67-80% of all strokes. Thrombolysis is used during the acute phase in only 2-5% of ischemic patients. Clinical trials of candidate neuroprotective agents have failed to identify viable therapies for ischemic stroke in humans. There is therefore a great need for new therapeutic strategies, considering that not all brain cells die immediately after ischemic stroke.
Related Concept Videos
Inhibition of Cdk Activity
Inhibition of CDK Activity
Ischemic Stroke l: Introduction
Ischemic Stroke ll: Pathophysiology
