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Updated: May 26, 2026
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In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Possible vitreous involvement in a case with rapidly progressing choroidal neovascularization
Masayuki Hata1, Akio Oishi, Michiko Mandai
1Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe, Japan.
Indian Journal of Ophthalmology
|January 6, 2012
Summary
Photodynamic therapy for subfoveal choroidal neovascularization (CNV) can lead to unexpected retinal penetration. This case suggests vascular endothelial growth factor or vitreous traction may cause adverse effects during treatment.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neovascularization
Background:
- Subfoveal choroidal neovascularization (CNV) is a leading cause of vision loss in various retinal diseases.
- Photodynamic therapy (PDT) is a common treatment for exudative AMD and other conditions causing CNV.
- Effective management of CNV is crucial for preserving visual function.
Observation:
- A 65-year-old male patient with subfoveal CNV received multiple PDT sessions.
- Despite treatment, the CNV progressively enlarged and invaded the retinal layers.
- Vitreous adhesion to supraretinal fibrotic tissue was noted at the CNV border.
Findings:
- The case demonstrated an unusual progression of CNV following PDT, with retinal penetration.
- Potential mechanisms for this adverse event include upregulation of vascular endothelial growth factor (VEGF).
- Enhanced vitreous traction on the fibrotic tissue was also considered a contributing factor.
Implications:
- This case highlights a potential, unexpected side effect of PDT in managing CNV.
- Further research is needed to understand and mitigate risks associated with PDT.
- Clinicians should be aware of potential complications like retinal invasion and vitreous adhesion during CNV treatment.
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