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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
What is the Endocrine System?00:46

What is the Endocrine System?

The endocrine system sends hormones—chemical signals—through the bloodstream to target cells—the cells the hormones selectively affect. These signals are produced in endocrine cells, secreted into the extracellular fluid, and then diffuse into the blood. Eventually, they diffuse out of the blood and bind to target cells which have specialized receptors to recognize the hormones.
Structures of the Endocrine System00:59

Structures of the Endocrine System

The intricate framework of the endocrine system encompasses a diverse array of glands, with their target tissues and organs strategically distributed throughout the body. Central to this network are the endocrine glands, specialized structures that lack ducts and release hormones directly into the interstitial fluid. Notably, the hypothalamus, a vital neuroendocrine organ situated in the brain, governs neural functions and serves as a potent source of hormonal regulation. Near the hypothalamus...
An Overview of the Endocrine System01:10

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The endocrine system, a complex network of glands, orchestrates physiological balance within the body through the production and secretion of hormones. These hormones are chemical messengers in intercellular communication, acting as conduits between the secretory cells and distant target sites. They traverse the circulatory system by being released into the extracellular fluid, and their impact is specific to cells possessing receptors for a particular hormone.
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The Endocrine System01:29

The Endocrine System

The endocrine system is an extensive network of glands – organs or tissues in the body that create chemicals that control many bodily functions, that secrete hormones, which are chemical messengers that play essential roles in regulating various bodily functions. These hormones are secreted into the bloodstream and travel throughout the body. They require specific receptors to convey signals to cells possessing these corresponding receptors. This complex signaling mechanism ensures that every...
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Related Experiment Video

Updated: May 26, 2026

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[The vitamin D endocrine system].

Luiz Claudio Gonçalves de Castro1

  • 1Laboratório de Pesquisas em Pediatria, Departamento de Pediatria, Faculdade de Medicina, Universidade de Brasília, DF, Brasil. lcgcastro@unb.br

Arquivos Brasileiros De Endocrinologia E Metabologia
|January 6, 2012
PubMed
Summary

The vitamin D endocrine system regulates calcium, bone health, and 3% of the human genome. Accurate lab assays are crucial for assessing vitamin D status and its impact on overall health.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genomics

Context:

  • The vitamin D endocrine system involves secosteroids, including 1,25-dihydroxy-vitamin D (1,25(OH)(2)D), its metabolites, binding protein (DBP), nuclear receptor (VDR), and cytochrome P450 enzymes.
  • The active metabolite 1,25(OH)(2)D exerts its effects via the VDR, a nuclear receptor found in most human cells.

Purpose:

  • To highlight the multifaceted roles of the vitamin D endocrine system beyond calcium metabolism.
  • To emphasize the importance of accurate laboratory assays for evaluating vitamin D status and its clinical-metabolic implications.

Summary:

  • Vitamin D regulates calcium and bone health, and influences approximately 3% of the human genome.
  • It plays a role in cell growth, differentiation, apoptosis, and the regulation of immune, cardiovascular, musculoskeletal, and insulin systems.

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  • Accurate and reproducible laboratory assays are essential for reliable assessment of vitamin D status and its impact on individual health.

    • Impact:

    • Understanding the broad functions of the vitamin D endocrine system is critical for maintaining systemic metabolic equilibrium.
    • Reliable diagnostic tools are needed to accurately reflect vitamin D status and guide clinical decisions.
    • This research underscores the significance of vitamin D in overall health and disease prevention.