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Metabolic evaluation of young women with congenital adrenal hyperplasia
Gabrielle Sormanti Schnaider-Rezek1, Sofia Helena Valente de Lemos-Marini, Maria Tereza Matias Baptista
1Department of Pediatrics, Pediatric Endocrinology Unit, Center for Investigations in Pediatric, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil.
Objective:
To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage.
Subjects And Methods:
We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH.
Results:
BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose.
Conclusions:
Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.
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