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Autoantibodies from patients with localized and generalized bullous pemphigoid immunoprecipitate the same 230-kd
N Domloge-Hultsch1, L Utecht, W James
1Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Md 20814-4799.
Abstract:
Two patients demonstrating the typical clinical, histologic, and immunopathologic features of nonscarring localized bullous pemphigoid are described. These patients possess circulating IgG autoantibodies that bind the epidermal side of 1.0-mol/L sodium chloride-split human skin in indirect immunofluorescence microscopy. Immunnoprecipitation studies demonstrate that these patients have circulating autoantibodies that immunoprecipitate the same 230-kd bullous pemphigoid antigen that is precipitated by autoantibodies from patients with generalized bullous pemphigoid. These findings indicate that localized bullous pemphigoid is a true clinical variant of generalized pemphigoid rather than a separate nosologic entity.