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Updated: May 26, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
Published on: July 28, 2022
N'-(5-Bromo-2-hy-droxy-benzyl-idene)-3-nitro-benzohydrazide methanol mono-solvate
1Department of Chemistry, Jiaying University, Meizhou 514015, People's Republic of China.
This study details the crystal structure of a bromo-substituted hydrazone molecule, highlighting its specific molecular geometry and hydrogen bonding interactions. The findings reveal how these interactions influence the compound's solid-state arrangement and molecular assembly.
Area of Science:
- Crystallography
- Organic Chemistry
- Supramolecular Chemistry
Background:
- Hydrazone derivatives are known for diverse biological activities.
- Understanding the solid-state structure is crucial for predicting chemical properties.
- Intermolecular interactions dictate crystal packing and material properties.
Purpose of the Study:
- To elucidate the crystal structure of a novel bromo-substituted hydrazone compound.
- To analyze the intramolecular and intermolecular hydrogen bonding networks.
- To investigate the influence of solvent molecules on crystal formation.
Main Methods:
- Single-crystal X-ray diffraction analysis was performed.
- The crystal structure was solved and refined.
- Hydrogen bonding and molecular geometry were characterized.
Main Results:
- The compound crystallizes as a methanol solvate (C(14)H(10)BrN(3)O(4)·CH(4)O).
- A small dihedral angle (5.8°) between benzene rings indicates near-planarity.
- Intramolecular O-H⋯N and intermolecular N-H⋯O hydrogen bonds form S(6) and chain motifs, respectively.
Conclusions:
- The crystal structure reveals specific hydrogen bonding patterns influencing molecular conformation.
- The methanol solvent molecule participates in hydrogen bonding.
- The study provides insights into the supramolecular assembly of hydrazone derivatives.
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