Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic Acids to Methylesters: Alkylation using Diazomethane

Carboxylic acids react with diazomethane in an ether solvent via alkylation at the carboxylate oxygen atom to give methyl esters of the corresponding acid with excellent yields.

Basicity of Heterocyclic Aromatic Amines

Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).

Phase II Reactions: Methylation Reactions

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

N-Benzyl-4-methyl-6-phenyl-pyrimidin-2-amine.

Acta crystallographica. Section E, Structure reports online·2012

Same author

N-Butyl-4,6-diphenyl-pyrimidin-2-amine.

Acta crystallographica. Section E, Structure reports online·2012

Same author

Ethyl 7-pivaloyl-amino-1,8-naphthyridine-2-carboxyl-ate sesquihydrate.

Acta crystallographica. Section E, Structure reports online·2011

Same author

Bis(ferrocenecarbaldehyde 4-methyl-thio-semicarbazonato-κN,S)zinc(II) methanol solvate.

Acta crystallographica. Section E, Structure reports online·2011

Same author

Poly[[diaqua-(3-carb-oxy-5-nitro-ben-zo-ato)(μ-5-nitro-benzene-1,3-dicarboxyl-ato)neodymium(III)] 2.5-hydrate].

Acta crystallographica. Section E, Structure reports online·2011

Same author

2-((E)-{2-[(E)-2,3-Dihydroxy-benzyl-ideneamino]-5-methyl-phen-yl}iminiometh-yl)-6-hydroxy-phenolate.

Acta crystallographica. Section E, Structure reports online·2011

Search research articles

Related Experiment Video

Updated: May 26, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

Methyl pyrido[2,3-b]pyrazine-3-carboxyl-ate.

Hoong-Kun Fun, Madhukar Hemamalini, Anita Hazra

Acta Crystallographica. Section E, Structure Reports Online

|January 6, 2012

Summary

This study details the crystal structure of C(9)H(7)N(3)O(2), revealing two independent molecules. The structure is stabilized by hydrogen bonds and features significant pyrazine-pyrazine and pyridine-pyrazine π-π interactions.

More Related Videos

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

Related Experiment Videos

Last Updated: May 26, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

Area of Science:

Crystallography
Supramolecular Chemistry
Organic Chemistry

Background:

Understanding molecular interactions is crucial for materials science.
Crystal structure analysis provides fundamental insights into intermolecular forces.
The title compound, C(9)H(7)N(3)O(2), is a molecule of interest for its potential applications.

Purpose of the Study:

To elucidate the crystal structure of the title compound, C(9)H(7)N(3)O(2).
To identify and characterize the intermolecular interactions stabilizing the crystal lattice.
To investigate the presence and nature of π-π stacking interactions within the crystal.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the crystal structure.
Analysis of the crystal structure involved identifying hydrogen bonds (C-H⋯O and C-H⋯N).
π-π interaction distances between aromatic rings (pyrazine-pyrazine and pyridine-pyrazine) were calculated.

Main Results:

The asymmetric unit contains two independent molecules of C(9)H(7)N(3)O(2).
The crystal structure is stabilized by a three-dimensional network of C-H⋯O and C-H⋯N hydrogen bonds.
Significant pyrazine-pyrazine (3.6994 Å) and pyridine-pyrazine (3.6374 Å) π-π interactions were observed.

Conclusions:

The crystal packing of C(9)H(7)N(3)O(2) is dictated by a combination of hydrogen bonding and π-π stacking.
The identified intermolecular interactions provide a basis for understanding the compound's solid-state properties.
This structural characterization contributes to the broader understanding of nitrogen-containing heterocyclic compounds.