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Hemolysin as a marker for Serratia.

Y Ruan1, V Braun

  • 1Universität Tübingen, Federal Republic of Germany.

Archives of Microbiology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

All Serratia marcescens strains are hemolytic, possessing hemolysin genes. These genes were found in other Serratia species but not in common enteric bacteria, indicating specificity.

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Area of Science:

  • Microbiology
  • Genetics

Background:

  • Hemolytic activity in Serratia marcescens strains was investigated.
  • Previous classifications of nonhemolytic strains were re-evaluated.

Purpose of the Study:

  • To determine the genetic basis of hemolysin production in Serratia species.
  • To assess the prevalence and specificity of hemolysin genes within the Serratia genus and related bacteria.

Main Methods:

  • DNA hybridization using hemolysin gene probes.
  • Analysis of restriction patterns of hemolysin loci.
  • Testing for hemolysin activity and gene presence across various bacterial species.

Main Results:

  • All 33 Serratia marcescens strains tested were hemolytic, including previously nonhemolytic clinical isolates.

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  • Hemolysin genes hybridized with DNA from hemolytic Serratia species (S. liquefaciens, S. kiliensis, etc.).
  • S. ficaria and S. marinorubra possess a distinct, smaller hemolysin not detected by S. marcescens probes; other Serratia species sometimes co-expressed both hemolysins.
  • No hybridization occurred with DNA from non-Serratia species (e.g., E. coli, Salmonella), confirming probe specificity.

    • Conclusions:

    • Serratia marcescens hemolysin genes are widespread within the Serratia genus.
    • The hemolysin DNA probes are specific for Serratia, with hemolysin genes rarely found in other genera.
    • Hemolytic activity in Serratia is primarily mediated by specific hemolysin genes, with variations in gene locus restriction patterns observed.