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Diabetic Foot Ulcer

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Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Related Experiment Video

Updated: May 26, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Progress in stem cell therapy for the diabetic foot.

Xiao-Yan Jiang¹, De-Bin Lu, Bing Chen

¹Department of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Diabetes Research and Clinical Practice

|January 7, 2012

Summary

Diabetic foot complications, including poor circulation, persist despite standard treatments. Stem cell therapy offers new hope for improving blood flow and healing diabetic foot ulcers.

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Last Updated: May 26, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Creation and Transplantation of an Adipose-derived Stem Cell (ASC) Sheet in a Diabetic Wound-healing Model

Published on: August 4, 2017

Area of Science:

Diabetic foot complications
Vascular biology
Regenerative medicine

Background:

Diabetic foot is a severe diabetes complication involving vasculopathy, neuropathy, tissue damage, and infection.
Ischemia-induced vasculopathy significantly impacts diabetic foot pathogenesis and outcomes.
Conventional revascularization methods have limited success, leading to persistent high amputation rates.

Purpose of the Study:

To explore stem cell therapy as an alternative treatment for diabetic foot.
To investigate the potential of stem cells in enhancing revascularization and wound healing.
To address the unmet need for effective diabetic foot treatments.

Main Methods:

Review of existing literature on diabetic foot complications.
Analysis of stem cell therapy mechanisms for promoting angiogenesis.
Evaluation of stem cell potential in alleviating limb ischemia and improving wound healing.

Main Results:

Stem cell therapy shows promise in stimulating new blood vessel formation (angiogenesis).
Potential for stem cells to improve limb ischemia and enhance wound healing in diabetic foot patients.
Highlights the need for further research and clinical trials.

Conclusions:

Stem cell therapy presents a promising alternative for treating diabetic foot complications.
Further investigation is warranted to establish efficacy and safety in clinical settings.
Offers a potential new therapeutic avenue for patients suffering from diabetic foot disease.