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Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams
Akuodor Godwin Christian1, Amos Grace Mfon, Essien Augustine Dick
1Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria. goddyakuodor@yahoo.com
Objective:
To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf.
Methods:
The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies.
Results:
The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg).
Conclusions:
The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
