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Evaluation of the antimalarial potential of Icacina senegalensis Juss (Icacinaceae)
Essien David-Oku1, Obiajunwa-Otteh Juliet Ifeoma1, Akuodor Godwin Christian2
1Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria.
Objective:
To evaluate in vivo antimalarial activity of methanol leaf extract of Icacina senegalensis.
Methods:
The extract was investigated for activity against early and established malaria infections using Swiss albino mice infected with Plasmodium berghei at dose levels of 25, 50 and 100 mg/kg. Chloroquine (10 mg/kg) was used as positive control.
Results:
A dose dependent chemo-suppression of the parasites was observed at different dose levels of the extract tested with a considerable mean survival time.
Conclusions:
The results support further investigation on components of traditional medicines as potential new antimalarial agents.
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