[Principles of the morphofunctional classification of granulocyte deficiencies]

Area of Science:

• Hematology
• Immunology
• Pathology

Context:

• Neutrophilic leukocytes (NL) play a critical role in immune response.
• Granulocytic deficiencies (GD) represent a spectrum of hematological disorders affecting neutrophil function.
• Accurate classification and diagnosis of GD are essential for effective patient management.

Purpose:

• To develop a novel classification system for granulocytic deficiencies (GD).
• To establish clinicomorphological criteria for the diagnosis of GD.
• To differentiate functional failures characteristic of each GD form.

Summary:

• A classification of granulocytic deficiencies (GD) was developed using qualitative and quantitative indices of the plasmatic-cellular system of neutrophilic leukocytes (NL).
• Four distinct forms of GD were identified: agranulocytosis, granulocytasthenia, myeloproliferative conditions, and inflammatory leukocytosis.
• A diagnostic triad comprising tissue necrosis, microbism, and inflammatory infiltration was proposed as a clinicomorphological criterion for GD. Each GD form exhibits unique functional failure characteristics.

Impact:

• This classification provides a structured framework for understanding and diagnosing granulocytic deficiencies.
• The proposed diagnostic criteria can aid clinicians in identifying GD more accurately.
• Understanding the specific functional failures associated with each GD form can guide targeted therapeutic strategies.