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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
Levels of blood periostin decrease after acute myocardial infarction and are negatively associated with ventricular
Chi-Wen Cheng1, Chao-Hung Wang, Ju-Fang Lee
1Heart Failure Center, Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, Taoyuan, Taiwan.
Insights
Acute myocardial infarction (AMI) is linked to lower periostin (PN) levels. Lower PN concentrations after AMI predict poorer cardiac function three months later, indicating PN
Area of Science:
- Cardiology
- Biomarker Research
- Regenerative Medicine
Background:
- Periostin (PN) promotes cardiomyocyte cell cycle reentry and improves cardiac function post-AMI.
- Previous research suggests PN's therapeutic potential in heart repair.
Purpose of the Study:
- Investigate periostin (PN) level changes following acute myocardial infarction (AMI).
- Determine the prognostic value of PN concentrations for cardiac function after AMI.
Main Methods:
- Recruited 123 patients (45 AMI, 45 stable CAD, 33 controls).
- Measured blood periostin (PN) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels.
- Assessed cardiac function using echocardiography at 3 months post-AMI.
Main Results:
- AMI patients exhibited significantly lower PN levels early post-event compared to CAD and control groups.
- PN levels further decreased in AMI patients within 8-10 days.
- Pre-discharge PN levels negatively correlated with left ventricular ejection fraction and positively with ventricular diameters at 3 months post-AMI.
Conclusions:
- Acute myocardial infarction is associated with a significant decrease in circulating periostin levels.
- Periostin concentrations measured before hospital discharge serve as a predictor of cardiac function recovery three months after AMI.
Background:
A recent study showed that periostin (PN) induced reentry of differentiated cardiomyocytes into the cell cycle and improved heart function after acute myocardial infarction (AMI). This study sought to investigate whether PN levels increase after AMI and whether they provide prognostic value.
Methods And Results:
We recruited 123 patients: 45 with AMI, 45 with stable coronary artery disease (CAD), and 33 healthy controls (CON). Blood PN and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels were measured. Echocardiography was repeated 3 months after AMI. In the AMI group, the PN levels 1.3 ± 1.2 days after AMI were significantly lower than those in the CAD and CON groups (175 ± 60, 245 ± 68, and 232 ± 63 ng/mL, respectively, P = 0.001). The NT-pro-BNP levels were significantly higher in the AMI group, compared to the CON and CAD groups (10.07 ± 28.2 [median, 0.70] vs 0.08 ± 0.06 [median, 0.05] and 1.1 ± 4.2 [median, 0.09] ng/mL, respectively; P = 0.02). The PN levels further decreased 8 ± 2 days after AMI (from 175 ± 60 to 143 ± 57 ng/mL; P = 0.003). However, NT-pro-BNP levels did not significantly change. With respect to the echocardiographic parameters 3 months after AMI, the PN levels measured before discharge were negatively associated with the left ventricular ejection fraction (rs = -0.50; P = 0.001), end diastolic (rs = 0.42; P = 0.009) and systolic (rs = 0.46; P = 0.004) diameters. The NT-pro-BNP levels were not significantly correlated with these parameters.
Conclusion:
Acute myocardial infarction is associated with a decrease in blood PN levels, and PN concentrations predict cardiac function 3 months after AMI.
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