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High throughput production of single core double emulsions in a parallelized microfluidic device
Mark B Romanowsky1, Adam R Abate, Assaf Rotem
1School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, USA.
Lab on a Chip
|January 7, 2012
Summary
Researchers developed a parallel microfluidic device for mass-producing uniform double emulsions. This high-throughput method achieves over 1 kg/day production with less than 6% diameter variation for microcapsule templates.
Area of Science:
- Materials Science
- Chemical Engineering
- Fluid Dynamics
Background:
- Double emulsions are valuable templates for creating microcapsules and complex particles.
- Existing methods lack the uniformity and throughput required for large-scale production.
Purpose of the Study:
- To present a novel parallel numbering-up design for microfluidic double emulsion devices.
- To achieve high uniformity and high throughput in double emulsion production.
Main Methods:
- Developed a parallel numbering-up microfluidic design.
- Incorporated up to 15 dropmaker units in 2D or 3D arrays.
- Demonstrated production of single-core double emulsion drops.
Main Results:
- Achieved production rates exceeding 1 kg/day.
- Maintained diameter variation below 6% for uniformity.
- Demonstrated scalability for industrial production (tons per year).
Conclusions:
- The parallel numbering-up design integrates microfluidic control with mass production capabilities.
- This approach enables industrial-scale manufacturing of uniform double emulsions.
- Facilitates the creation of microcapsules and complex particles at scale.
