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IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis
Lin Cui1, Jing Jia, Chun-Fen Ma
1Central Laboratory, the First Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou, People's Republic of China.
Objectives:
The purpose of this study was to evaluate the effects of interleukin-13 (IL-13) polymorphisms on the risk of asthma using a meta-analysis.
Design And Methods:
Fifteen publications were identified by searching Pubmed, Embase, ISI, OVID, and EBSCO databases. Odds ratios with corresponding 95% confidence intervals were computed to estimate the association between IL-13 polymorphisms and risk of asthma.
Results:
The polymorphisms of R130Q (rs20541) and -1112C/T (rs1800925) in IL-13 gene were associated with significantly increased risks of asthma in overall analyses. Subgroup analyses showed that the elevated risks occurred in adult-onset asthma, Caucasians, and high quality studies.
Conclusions:
This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.
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